1. QUOTE from:
    Breast cancer spread triggered by a cleaver-wielding protein on cancer cell's surface
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    According to Zena Werb, "In humans, breast cancers that have diminished amounts of Lkb1 show strong hepsin expression. Since hepsin sits on the cell membrane, it should be accessible to drugs. We believe that hepsin forms a novel target for treatment of a subset of breast cancer patients." Dr Juha Klefström's research group is affiliated with Institute of Biomedicine and Genome-Scale Research Program, Medical Faculty (Biomedicum Helsinki), Unversity of Helsinki. Full Article at EurekAlert
    In humans, breast cancers that have diminished amounts of Lkb1 show strong hepsin expression. Since hepsin sits on the cell membrane, it should be accessible to drugs. We believe that hepsin forms a novel target for treatment of a subset of breast cancer patients.
    SOURCE: EurekAlert 4 months ago
All quotes from:
Breast cancer spread triggered by a cleaver-wielding protein on cancer cell's surface
  1. We think that it is the combination of Myc empowered cell cycle and cell's ability to destroy basement membrane, which contributed to the vicious tumor formation
    SOURCE: EurekAlert 4 months ago
  2. I was disappointed with the results. However, then I realized that even though broken basement membrane may give more freedom for cells to proliferate, the cells may just lay there, resting, and not start to over-proliferate unless they are pushed to cell division cycle.
    SOURCE: EurekAlert 4 months ago
  3. These findings led us to ask an obvious question: does Hepsin mediated degradation of basement membrane make epithelial cells more cancer-prone?
    SOURCE: EurekAlert 4 months ago
  4. If we could delay or prevent a tumor from switching from one that grows in place to one that invades, then that would be a major milestone in cancer treatment
    SOURCE: EurekAlert 4 months ago

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